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RetrosynthesisML

Reviews

  • (2024, WIREs Comput Mol Sci) Recent advances in deep learning for retrosynthesis. [Page]

Literature

2024

  • (Syntheseus, Faraday Discuss) Re-evaluating Retrosynthesis Algorithms with Syntheseus. [Link]
  • (Digital Discovery) Models matter: the impact of single-step retrosynthesis on synthesis planning. [Link]
  • (EditRetro, Nat Commun) Retrosynthesis prediction with an iterative string editing model. [Page]
  • (Digital Discovery) Investigating the reliability and interpretability of machine learning frameworks for chemical retrosynthesis. [Page]
  • (ReSynZ, J Chem Theory Comput) Retrosynthesis Zero: self-improving global synthesis planning using reinforcement learning. [Page]
    • Policy improvement with MCTS suggested actions.
  • (MEEA*, Commun Chem) Efficient retrosynthetic planning with MCTS exploration enhanced A* search. [Page]
    • A* search with exploration from MCTS.

2023

  • (Graph2Edit, Nat Commun) Retrosynthesis prediction using an end-to-end graph generative architecture for molecular graph editing. [Page]
    • Semi-template retrosynthesis with edit vocabulary and end-to-end architecture.

2022

  • (R-SMILES, Chem Sci) Root-aligned SMILES: a tight representation for chemical reaction prediction. [Page]
    • Molecule representation with minimal edit distance between product and reactants.

2021

  • (GraphRetro, NeurIPS) Learning graph models for retrosynthesis prediction. [Page]
    • Semi-template retrosynthesis with subgraph vocabulary.
  • (Kim, ICML) Self-improving retrosynthesis planning. [Page]
    • Backward reaction model learned by imitating RETRO*-generated realistic data.

2020

  • (Retro*, ICML) Retro*: learning retrosynthetic planning with neural guided A* search. [Page]
    • Pioneer work in retrosynthetic planning; search with a value function.

2019

  • (Schreck, ACS Cent Sci) Learning retrosynthetic planning through simulated experience. [Page]
    • Retrosynthesis with deep reinforcement learning.

Datasets

  • USPTO-50k [Page]
  • USPTO-MIT
  • USPTO-FULL

Tutorials

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Mianchu's repository for retrosynthesis.

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