diff --git a/.cargo/mutants.toml b/.cargo/mutants.toml
index b6ed18c553..6477f498ed 100644
--- a/.cargo/mutants.toml
+++ b/.cargo/mutants.toml
@@ -1,5 +1,5 @@
 additional_cargo_args = ["--all-features"]
-examine_globs = ["units/src/**/*.rs"]
+examine_globs = ["units/src/**/*.rs", "primitives/src/**/*.rs"]
 exclude_globs = [
     "units/src/amount/verification.rs" # kani tests
 ]
@@ -8,20 +8,25 @@ exclude_re = [
     "impl Arbitrary",
     "impl Display",
     ".*Error",
-    # --------------------------------------------Crate-specific exclusions--------------------------------------------
+    "deserialize", # Skip serde mutation tests
+    "Iterator", # Mutating operations in an iterator can result in an infinite loop
+
+    # ----------------------------------Crate-specific exclusions----------------------------------
     # Units
     # src/amount/mod.rs
     "parse_signed_to_satoshi", # Can't kill all mutants since there is no denomination smaller than Satoshi
     "fmt_satoshi_in", # Related to formatting/display
     "dec_width", # Replacing num /= 10 with num %=10 in a loop causes a timeout due to infinite loop
-    # src/fee_rate/serde.rs
-    "as_sat_per_kwu::opt::deserialize::<impl Visitor for VisitOpt>.*", # Replaces return value with Ok(Default::default()), which is the same as Ok(None)
-    "as_sat_per_vb_floor::opt::deserialize::<impl Visitor for VisitOpt>.*", # Replaces return value with Ok(Default::default()), which is the same as Ok(None)
-    "as_sat_per_vb_ceil::opt::deserialize::<impl Visitor for VisitOpt>.*", # Replaces return value with Ok(Default::default()), which is the same as Ok(None)
-    # src/amount/serde.rs
-    "as_sat::opt::deserialize::<impl Visitor for VisitOptAmt<X>>.*", # Replaces return value with Ok(Default::default()), which is the same as Ok(None)
-    "as_btc::opt::deserialize::<impl Visitor for VisitOptAmt<X>>.*", # Replaces return value with Ok(Default::default()), which is the same as Ok(None)
-    "as_str::opt::deserialize::<impl Visitor for VisitOptAmt<X>>.*", # Replaces return value with Ok(Default::default()), which is the same as Ok(None)
     # src/locktime/relative.rs
-    "Time::to_consensus_u32" # It will replace | with ^, which will return the same value since the XOR is always taken against the u16 and an all-zero bitmask
+    "Time::to_consensus_u32", # Mutant from replacing | with ^, this returns the same value since the XOR is taken against the u16 with an all-zero bitmask
+
+    # primitives
+    "Sequence::from_512_second_intervals", # Mutant from replacing | with ^, this returns the same value since the XOR is taken against the u16 with an all-zero bitmask
+    "Opcode::classify", # Not possible to kill all mutants without individually checking every opcode classification
+    "Block<Checked>::cached_witness_root", # Skip getters
+    "Block<Checked>::transactions", # Skip getters
+    "Script::to_bytes", # Deprecated
+    "decode_cursor", # Mutating operations in decode_cursor can result in an infinite loop
+    "fmt_debug", # Mutants from formatting/display changes
+    "fmt_debug_pretty", # Mutants from formatting/display changes
 ]