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Copy pathPathway531_agg_all.txt~
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Pathway531_agg_all.txt~
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"BiochemicalReaction2284"#"Association of LBP with LPS"#"0.02857142857142857"
"BiochemicalReaction2287"#"Transfer of LPS onto TLR4"#"0"
"BiochemicalReaction2288"#"CD14:LPS binds CR3"#"0"
"BiochemicalReaction2289"#"MAL(TIRAP) binds PIP2-rich regions in the plasma membrane"#"0"
"BiochemicalReaction2290"#"Endocytosis of TLR4:MD2:LPS:CD14"#"0"
"BiochemicalReaction2291"#"Endocytosis of TRAM (TICAM2)"#"0.5285714285714286"
"BiochemicalReaction2292"#"TLR4:MD2:LPS:CD14 recruits TRAM (TICAM2)"#"0"
"BiochemicalReaction2285"#"GPI-bound CD14 binds LPS"#"0.02857142857142857"
"BiochemicalReaction2286"#"Secreted CD14 binds LPS"#"0.02857142857142857"
"BiochemicalReaction2293"#"Activated TLR2/4 interacts with MAL(TIRAP)"#"0"
"BiochemicalReaction2294"#"Activated TLR2/4:MAL interacts with BTK"#"0"
"BiochemicalReaction2295"#"MAL is phosphorylated by BTK"#"0.014285714285714285"
"BiochemicalReaction2296"#"MyD88 forms a complex with MAL:activated TLR2/4"#"0"
"BiochemicalReaction2297"#"MyD88 oligomerization within the complex of activated TLR:Mal:MyD88"#"0"
"BiochemicalReaction2298"#"IRAK4 binds to the activated TLR receptor:Mal:MyD88 complex"#"0"
"BiochemicalReaction2299"#"IRAK4 autophosphorylation in the complex with activated TLR:MyD88:Mal"#"0.014285714285714285"
"BiochemicalReaction2300"#"IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:Mal complex"#"0"
"BiochemicalReaction2301"#"Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:Mal:activated TLR complex"#"0"
"BiochemicalReaction2302"#"First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal"#"0"
"BiochemicalReaction2303"#"Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal"#"0"
"BiochemicalReaction2304"#"Multiple IRAK1 autophosphorylation steps"#"0"
"BiochemicalReaction2305"#"TRAF6 binds to hp- IRAK1"#"0"
"BiochemicalReaction2306"#"TRAF6 binds to p-IRAK2"#"0"
"BiochemicalReaction2307"#"Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:Mal:p-IRAK4 complex"#"0"
"BiochemicalReaction2308"#"Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:Mal:p-IRAK4 complex"#"0"
"BiochemicalReaction2214"#"TRAF6 binds MEKK1"#"0"
"BiochemicalReaction2209"#"IRAK2 induces TRAF6 oligomerization"#"0"
"BiochemicalReaction2210"#"Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2"#"0"
"BiochemicalReaction2211"#"Activated TRAF6 synthesizes unanchored polyubiquitin chains"#"0"
"BiochemicalReaction2212"#"Activated TRAF6:p-IRAK2 interacts with TAK1 complex"#"0"
"BiochemicalReaction2213"#"Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3"#"0"
"BiochemicalReaction2205"#"Pellino binds hp-IRAK1:TRAF6"#"0"
"BiochemicalReaction2206"#"IRAK1 phosphorylates Pellino"#"0"
"BiochemicalReaction2207"#"Pellino ubiquitinates hp-IRAK1"#"0"
"BiochemicalReaction2208"#"NEMO subunit of IKK complex binds to activated IRAK1"#"0"
"BiochemicalReaction2215"#"Activated TAK1 mediates phosphorylation of the IKK Complex"#"0"
"BiochemicalReaction2216"#"Phospho-IKK Complex phosphorylates IkB within the IkB:NFkB Complex"#"0"
"BiochemicalReaction2217"#"Released NFkB complex is transported to nucleus"#"0"
"BiochemicalReaction2218"#"Activated TAK1 phosphorylates MKK4/MKK7"#"0"
"BiochemicalReaction2219"#"Phosphorylation of human JNKs by activated MKK4/MKK7"#"0"
"BiochemicalReaction2220"#"Activated human JNKs migrate to nucleoplasm"#"0.14285714285714285"
"BiochemicalReaction2221"#"activated human TAK1 phosphorylates MKK3/MKK6"#"0"
"BiochemicalReaction2222"#"Phosphorylated MKK3/MKK6 migrates to nucleus"#"0.04285714285714286"
"BiochemicalReaction2223"#"Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3"#"0"
"BiochemicalReaction2224"#""#"0"
"BiochemicalReaction2225"#"Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3"#"0"
"BiochemicalReaction51"#"Inactivation of MEK1 by p34cdc2"#"0.8428571428571429"
"BiochemicalReaction52"#"MEK1 binds ERK-1"#"0"
"BiochemicalReaction53"#"MEK1 phosphorylates ERK-1"#"0"
"BiochemicalReaction54"#"Dissociation of phospho-ERK-1:MEK1"#"0"
"BiochemicalReaction55"#"Dimerisation of phospho-ERK-1"#"0"
"BiochemicalReaction56"#"Nuclear translocation of phospho-ERK-1 dimer"#"0"
"BiochemicalReaction57"#"MEK2 binds ERK-2"#"0.07142857142857142"
"BiochemicalReaction58"#"MEK2 phosphorylates ERK-2"#"0"
"BiochemicalReaction59"#"Dissociation of phospho-ERK-2:MEK2"#"0"
"BiochemicalReaction60"#"Dimerisation of phospho-ERK-2"#"0.08571428571428572"
"BiochemicalReaction61"#"Nuclear translocation of phospho-ERK-2 dimer"#"0"
"BiochemicalReaction322"#"ERK1/2 activates ELK1"#"0"
"BiochemicalReaction323"#"ERK1/2 phosphorylates MSK1"#"0"
"BiochemicalReaction324"#"p38MAPK phosphorylates MSK1"#"0"
"BiochemicalReaction325"#"ERK1/2/5 activate RSK1/2/3"#"0.9428571428571428"
"BiochemicalReaction326"#"ERK5 activates the transcription factor MEF2"#"0"
"BiochemicalReaction327"#"ERKs are inactivated by protein phosphatase 2A"#"0"
"BiochemicalReaction328"#"ERKs are inactivated by dual-specific phosphatases (DUSPs)"#"0.9857142857142858"
"BiochemicalReaction329"#"MSK1 activates CREB"#"0.02857142857142857"
"BiochemicalReaction330"#"MSK1 activates ATF1"#"0.08571428571428572"
"BiochemicalReaction331"#"RSK1/2/3 phosphorylates CREB at Serine 133"#"0.08571428571428572"
"BiochemicalReaction332"#"MAPKAPK2 phosphorylates CREB at Serine 133"#"0.08571428571428572"
"BiochemicalReaction2226"#"Phosphorylated MAPKs phosphorylate ATF-2"#"0"
"BiochemicalReaction2227"#"Activated JNKs phosphorylate c-JUN"#"0.14285714285714285"
"BiochemicalReaction2228"#"c-FOS activation by phospho ERK1/2"#"0"
"BiochemicalReaction2229"#"Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer."#"0.11428571428571428"
"BiochemicalReaction2230"#"Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer."#"0.9285714285714286"
"BiochemicalReaction2232"#"TRAM:TLR4:MD2:LPS:CD14 recruits TRIF (TICAM1)"#"0"
"BiochemicalReaction2233"#"Viral dsRNA:TLR3 recruits TRIF (TICAM1)"#"0"
"BiochemicalReaction2234"#"Negative regulator SARM binds to TRIF"#"1"
"BiochemicalReaction2235"#"TRAF3 binds to TRIF:activated TLR3/4 complex"#"0"
"BiochemicalReaction2236"#"Auto-ubiquitination of TRAF3"#"0"
"BiochemicalReaction2237"#"Recruitment of TBK1/IKK epsilon to K63-poly-Ub-TRAF3:TRIF:activated TLR3/TLR4 followed by their phosphorylation"#"0"
"BiochemicalReaction2238"#"IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR"#"0"
"BiochemicalReaction2239"#"Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex"#"0"
"BiochemicalReaction2240"#"Dimerization of phosphorylated IRF3/IRF7"#"0.4"
"BiochemicalReaction2241"#"Dimerized phospho-IRF3/IRF7 is transported to the nucleus"#"1"
"BiochemicalReaction2242"#"TRIF:activated TLR3/TLR4 complex recruits RIP1"#"0.014285714285714285"
"BiochemicalReaction2243"#"K63-linked ubiquitination of RIP1 bound to the activated TLR complex"#"0"
"BiochemicalReaction2244"#"Nemo subunit of IKK complex binds polyubiquinated RIP1"#"0"
"BiochemicalReaction2245"#"TLR3/4-induced ripoptosome assembly"#"0"
"BiochemicalReaction2246"#"Caspase-8 processing"#"0.014285714285714285"
"BiochemicalReaction2247"#"RIP3 binds TRIF to mediate necroptosis"#"0"
"BiochemicalReaction2248"#"Activated TLR3/4:TRIF recruits TRAF6"#"0"
"BiochemicalReaction2249"#"Auto ubiquitination of TRAF6 bound to the activated TLR complex"#"0"
"BiochemicalReaction2250"#"Activated TLR:TRIF:K63-pUb-TRAF6 recruits TAK1complex"#"0"
"BiochemicalReaction2251"#"Activation of TAK1 complex bound to activated TLR"#"0"
"BiochemicalReaction2252"#"Phosphorylated TAK1 leaves activated TLR receptor complex"#"0"