diff --git a/.github/workflows/native-unix.yml b/.github/workflows/native-unix.yml
index 142d5f4be7..7b99003f0d 100644
--- a/.github/workflows/native-unix.yml
+++ b/.github/workflows/native-unix.yml
@@ -477,6 +477,8 @@ jobs:
       - name: Test Python Driver Flight SQL
         shell: bash -l {0}
         run: |
+          docker compose up -d flightsql-test
+          export ADBC_TEST_FLIGHTSQL_URI=grpc://localhost:41414
           env BUILD_ALL=0 BUILD_DRIVER_FLIGHTSQL=1 ./ci/scripts/python_test.sh "$(pwd)" "$(pwd)/build" "$HOME/local"
       - name: Build Python Driver PostgreSQL
         shell: bash -l {0}
diff --git a/python/adbc_driver_flightsql/tests/test_errors.py b/python/adbc_driver_flightsql/tests/test_errors.py
index ed44b6a3fa..3192475941 100644
--- a/python/adbc_driver_flightsql/tests/test_errors.py
+++ b/python/adbc_driver_flightsql/tests/test_errors.py
@@ -15,7 +15,11 @@
 # specific language governing permissions and limitations
 # under the License.
 
+import os
 import re
+import signal
+import threading
+import time
 
 import google.protobuf.any_pb2 as any_pb2
 import google.protobuf.wrappers_pb2 as wrappers_pb2
@@ -45,6 +49,41 @@ def test_query_cancel(test_dbapi):
             cur.fetchone()
 
 
+def test_query_cancel_async(test_dbapi):
+    with test_dbapi.cursor() as cur:
+        cur.execute("forever")
+
+        def _cancel():
+            time.sleep(2)
+            cur.adbc_cancel()
+
+        t = threading.Thread(target=_cancel, daemon=True)
+        t.start()
+
+        with pytest.raises(
+            test_dbapi.OperationalError,
+            match=re.escape("CANCELLED: [FlightSQL] context canceled"),
+        ):
+            cur.fetchone()
+
+
+def test_query_cancel_sigint(test_dbapi):
+    with test_dbapi.cursor() as cur:
+        cur.execute("forever")
+
+        # XXX: this handles the case of DoGet taking forever, but we also will
+        # want to test GetFlightInfo taking forever
+
+        def _cancel():
+            time.sleep(2)
+            os.kill(os.getpid(), signal.SIGINT)
+
+        t = threading.Thread(target=_cancel, daemon=True)
+        t.start()
+        with pytest.raises(KeyboardInterrupt):
+            cur.fetchone()
+
+
 def test_query_error_fetch(test_dbapi):
     with test_dbapi.cursor() as cur:
         cur.execute("error_do_get")
diff --git a/python/adbc_driver_manager/adbc_driver_manager/dbapi.py b/python/adbc_driver_manager/adbc_driver_manager/dbapi.py
index 1e86144c12..1113137195 100644
--- a/python/adbc_driver_manager/adbc_driver_manager/dbapi.py
+++ b/python/adbc_driver_manager/adbc_driver_manager/dbapi.py
@@ -55,6 +55,7 @@
 import adbc_driver_manager
 
 from . import _lib, _reader
+from .util import _blocking_call
 
 if typing.TYPE_CHECKING:
     import pandas
@@ -677,9 +678,12 @@ def execute(self, operation: Union[bytes, str], parameters=None) -> None:
             parameters, which will each be bound in turn).
         """
         self._prepare_execute(operation, parameters)
-        handle, self._rowcount = self._stmt.execute_query()
+
+        handle, self._rowcount = _blocking_call(
+            self._stmt.execute_query, [], {}, self._stmt.cancel
+        )
         self._results = _RowIterator(
-            _reader.AdbcRecordBatchReader._import_from_c(handle.address)
+            self._stmt, _reader.AdbcRecordBatchReader._import_from_c(handle.address)
         )
 
     def executemany(self, operation: Union[bytes, str], seq_of_parameters) -> None:
@@ -991,7 +995,7 @@ def adbc_read_partition(self, partition: bytes) -> None:
         handle = self._conn._conn.read_partition(partition)
         self._rowcount = -1
         self._results = _RowIterator(
-            pyarrow.RecordBatchReader._import_from_c(handle.address)
+            self._stmt, pyarrow.RecordBatchReader._import_from_c(handle.address)
         )
 
     @property
@@ -1095,7 +1099,8 @@ def fetch_record_batch(self) -> pyarrow.RecordBatchReader:
 class _RowIterator(_Closeable):
     """Track state needed to iterate over the result set."""
 
-    def __init__(self, reader: pyarrow.RecordBatchReader) -> None:
+    def __init__(self, stmt, reader: pyarrow.RecordBatchReader) -> None:
+        self._stmt = stmt
         self._reader = reader
         self._current_batch = None
         self._next_row = 0
@@ -1118,7 +1123,9 @@ def fetchone(self) -> Optional[tuple]:
         if self._current_batch is None or self._next_row >= len(self._current_batch):
             try:
                 while True:
-                    self._current_batch = self._reader.read_next_batch()
+                    self._current_batch = _blocking_call(
+                        self._reader.read_next_batch, [], {}, self._stmt.cancel
+                    )
                     if self._current_batch.num_rows > 0:
                         break
                 self._next_row = 0
diff --git a/python/adbc_driver_manager/adbc_driver_manager/util.py b/python/adbc_driver_manager/adbc_driver_manager/util.py
new file mode 100644
index 0000000000..57298bdee9
--- /dev/null
+++ b/python/adbc_driver_manager/adbc_driver_manager/util.py
@@ -0,0 +1,44 @@
+# Licensed to the Apache Software Foundation (ASF) under one
+# or more contributor license agreements.  See the NOTICE file
+# distributed with this work for additional information
+# regarding copyright ownership.  The ASF licenses this file
+# to you under the Apache License, Version 2.0 (the
+# "License"); you may not use this file except in compliance
+# with the License.  You may obtain a copy of the License at
+#
+#   http://www.apache.org/licenses/LICENSE-2.0
+#
+# Unless required by applicable law or agreed to in writing,
+# software distributed under the License is distributed on an
+# "AS IS" BASIS, WITHOUT WARRANTIES OR CONDITIONS OF ANY
+# KIND, either express or implied.  See the License for the
+# specific language governing permissions and limitations
+# under the License.
+
+import threading
+
+
+def _blocking_call(func, args, kwargs, cancel):
+    """Run functions that are expected to block off of the main thread."""
+    if threading.current_thread() is not threading.main_thread():
+        return func(*args, **kwargs)
+
+    ret = None
+
+    def _background_task():
+        nonlocal ret
+        ret = func(*args, **kwargs)
+
+    bg = threading.Thread(target=_background_task)
+    bg.start()
+
+    try:
+        bg.join()
+    except KeyboardInterrupt:
+        try:
+            cancel()
+        finally:
+            bg.join()
+            raise
+
+    return ret