diff --git a/common/src/main/java/com/copycatsplus/copycats/foundation/annotation/ModMixin.java b/common/src/main/java/com/copycatsplus/copycats/foundation/annotation/ModMixin.java
new file mode 100644
index 000000000..53b4ccb4a
--- /dev/null
+++ b/common/src/main/java/com/copycatsplus/copycats/foundation/annotation/ModMixin.java
@@ -0,0 +1,21 @@
+package com.copycatsplus.copycats.foundation.annotation;
+
+import com.copycatsplus.copycats.compat.Mods;
+
+import java.lang.annotation.ElementType;
+import java.lang.annotation.Retention;
+import java.lang.annotation.RetentionPolicy;
+import java.lang.annotation.Target;
+
+/*
+* This annotation is used to make mixins only enable themselves if the required mod(s) are installed
+*/
+
+@Target(ElementType.TYPE)
+@Retention(RetentionPolicy.RUNTIME)
+public @interface ModMixin {
+
+    Mods[] requiredMods();
+
+    boolean applyIfPresent() default true;
+}
diff --git a/common/src/main/java/com/copycatsplus/copycats/mixin/MixinPlugin.java b/common/src/main/java/com/copycatsplus/copycats/mixin/MixinPlugin.java
index d2a436a14..269df15d6 100644
--- a/common/src/main/java/com/copycatsplus/copycats/mixin/MixinPlugin.java
+++ b/common/src/main/java/com/copycatsplus/copycats/mixin/MixinPlugin.java
@@ -1,14 +1,24 @@
 package com.copycatsplus.copycats.mixin;
 
+import com.copycatsplus.copycats.compat.Mods;
+import com.copycatsplus.copycats.foundation.annotation.ModMixin;
 import com.llamalad7.mixinextras.MixinExtrasBootstrap;
+import org.objectweb.asm.Type;
+import org.objectweb.asm.tree.AnnotationNode;
 import org.objectweb.asm.tree.ClassNode;
+import org.slf4j.Logger;
+import org.slf4j.LoggerFactory;
 import org.spongepowered.asm.mixin.extensibility.IMixinConfigPlugin;
 import org.spongepowered.asm.mixin.extensibility.IMixinInfo;
+import org.spongepowered.asm.service.MixinService;
+import org.spongepowered.asm.util.Annotations;
 
+import java.io.IOException;
 import java.util.List;
 import java.util.Set;
 
 public class MixinPlugin implements IMixinConfigPlugin {
+    public static final Logger LOGGER = LoggerFactory.getLogger("Copycats+ | MixinPlugin");
     private boolean isFrameworkInstalled;
 
     @Override
@@ -29,9 +39,34 @@ public String getRefMapperConfig() {
 
     @Override
     public boolean shouldApplyMixin(String targetClassName, String mixinClassName) {
+        try {
+            List<AnnotationNode> annotationNodes = MixinService.getService().getBytecodeProvider().getClassNode(mixinClassName).visibleAnnotations;
+            if (annotationNodes == null) return true;
+
+            boolean shouldApply = true;
+            for (AnnotationNode node : annotationNodes) {
+                if (node.desc.equals(Type.getDescriptor(ModMixin.class))) {
+                    List<Mods> mods = Annotations.getValue(node, "requiredMods", true, Mods.class);
+                    boolean applyIfPresent = Annotations.getValue(node, "applyIfPresent", Boolean.TRUE);
+                    boolean anyModsLoaded = anyModsLoaded(mods);
+                    shouldApply = anyModsLoaded == applyIfPresent;
+                    LOGGER.debug("{} is {} being applied because the mod(s) {} are {} loaded", mixinClassName, shouldApply ? " " : " not ", mods, anyModsLoaded ? " " : " not ");
+                }
+            }
+            return shouldApply;
+        } catch (ClassNotFoundException | IOException e) {
+            LOGGER.error("An error occurred when checking if {} has the ModMixin annotation", mixinClassName, e);
+        }
         return isFrameworkInstalled; // this makes sure that forge's helpful mods not found screen shows up
     }
 
+    private static boolean anyModsLoaded(List<Mods> mods) {
+        for (Mods mod : mods) {
+            if (mod.isLoaded) return true;
+        }
+        return false;
+    }
+
     @Override
     public void acceptTargets(Set<String> myTargets, Set<String> otherTargets) {
 
diff --git a/common/src/main/java/com/copycatsplus/copycats/mixin/compat/additionalplacements/ConfigCommonMixin.java b/common/src/main/java/com/copycatsplus/copycats/mixin/compat/additionalplacements/ConfigCommonMixin.java
index 7f70027da..34b49bace 100644
--- a/common/src/main/java/com/copycatsplus/copycats/mixin/compat/additionalplacements/ConfigCommonMixin.java
+++ b/common/src/main/java/com/copycatsplus/copycats/mixin/compat/additionalplacements/ConfigCommonMixin.java
@@ -1,6 +1,8 @@
 package com.copycatsplus.copycats.mixin.compat.additionalplacements;
 
 import com.copycatsplus.copycats.Copycats;
+import com.copycatsplus.copycats.compat.Mods;
+import com.copycatsplus.copycats.foundation.annotation.ModMixin;
 import com.firemerald.additionalplacements.common.ConfigCommon;
 import net.minecraft.resources.ResourceLocation;
 import org.spongepowered.asm.mixin.Mixin;
@@ -14,6 +16,7 @@
  * <p>
  * Will appear to error but works and builds fine.
  */
+@ModMixin(requiredMods = Mods.ADDITIONAL_PLACEMENTS)
 @Pseudo
 @Mixin(value = {ConfigCommon.class})
 public class ConfigCommonMixin {
diff --git a/common/src/main/java/com/copycatsplus/copycats/mixin/compat/additionalplacements/PlacementBlockMixin.java b/common/src/main/java/com/copycatsplus/copycats/mixin/compat/additionalplacements/PlacementBlockMixin.java
index 0201c5fe0..3af03660c 100644
--- a/common/src/main/java/com/copycatsplus/copycats/mixin/compat/additionalplacements/PlacementBlockMixin.java
+++ b/common/src/main/java/com/copycatsplus/copycats/mixin/compat/additionalplacements/PlacementBlockMixin.java
@@ -1,5 +1,7 @@
 package com.copycatsplus.copycats.mixin.compat.additionalplacements;
 
+import com.copycatsplus.copycats.compat.Mods;
+import com.copycatsplus.copycats.foundation.annotation.ModMixin;
 import com.copycatsplus.copycats.foundation.copycat.ICopycatBlock;
 import com.firemerald.additionalplacements.block.AdditionalPlacementBlock;
 import net.minecraft.world.level.block.*;
@@ -11,6 +13,7 @@
 /**
  * Always report that our blocks have no extra states added by AdditionalPlacements.
  */
+@ModMixin(requiredMods = Mods.ADDITIONAL_PLACEMENTS)
 @Mixin(
         value = {
                 AdditionalPlacementBlock.class,
diff --git a/common/src/main/java/com/copycatsplus/copycats/mixin/compat/diagonalfences/FenceBlockMixin.java b/common/src/main/java/com/copycatsplus/copycats/mixin/compat/diagonalfences/FenceBlockMixin.java
index 09024cdd2..98495e7a2 100644
--- a/common/src/main/java/com/copycatsplus/copycats/mixin/compat/diagonalfences/FenceBlockMixin.java
+++ b/common/src/main/java/com/copycatsplus/copycats/mixin/compat/diagonalfences/FenceBlockMixin.java
@@ -1,5 +1,7 @@
 package com.copycatsplus.copycats.mixin.compat.diagonalfences;
 
+import com.copycatsplus.copycats.compat.Mods;
+import com.copycatsplus.copycats.foundation.annotation.ModMixin;
 import com.copycatsplus.copycats.foundation.copycat.ICopycatBlock;
 import net.minecraft.world.level.block.CrossCollisionBlock;
 import net.minecraft.world.level.block.FenceBlock;
@@ -13,6 +15,7 @@
  * <p>
  * This patch has to be applied after Diagonal Fences modifies the FenceBlock class
  */
+@ModMixin(requiredMods = Mods.DIAGONAL_FENCES)
 @Mixin(value = FenceBlock.class, priority = 1100)
 public abstract class FenceBlockMixin extends CrossCollisionBlock {
 
diff --git a/common/src/main/java/com/copycatsplus/copycats/mixin/compat/radium/PathNodeDefaultsMixin.java b/common/src/main/java/com/copycatsplus/copycats/mixin/compat/radium/PathNodeDefaultsMixin.java
index a93a06068..5b2c7c376 100644
--- a/common/src/main/java/com/copycatsplus/copycats/mixin/compat/radium/PathNodeDefaultsMixin.java
+++ b/common/src/main/java/com/copycatsplus/copycats/mixin/compat/radium/PathNodeDefaultsMixin.java
@@ -1,6 +1,8 @@
 package com.copycatsplus.copycats.mixin.compat.radium;
 
+import com.copycatsplus.copycats.compat.Mods;
 import com.copycatsplus.copycats.content.copycat.slab.CopycatSlabBlock;
+import com.copycatsplus.copycats.foundation.annotation.ModMixin;
 import com.llamalad7.mixinextras.injector.wrapoperation.Operation;
 import com.llamalad7.mixinextras.injector.wrapoperation.WrapOperation;
 import net.minecraft.world.level.block.Block;
@@ -13,6 +15,7 @@
 /**
  * Make sure Radium's pathfinding algorithm considers slabs properly, since they do not extend from {@link net.minecraft.world.level.block.SlabBlock}.
  */
+@ModMixin(requiredMods = Mods.INDIUM)
 @Mixin(targets = "me.jellysquid.mods.lithium.common.ai.pathing.PathNodeDefaults")
 @Pseudo
 public class PathNodeDefaultsMixin {
diff --git a/common/src/main/java/com/copycatsplus/copycats/mixin/compat/rubidium/BlockOcclusionCacheMixin.java b/common/src/main/java/com/copycatsplus/copycats/mixin/compat/rubidium/BlockOcclusionCacheMixin.java
index deb3d83a7..b2d74029a 100644
--- a/common/src/main/java/com/copycatsplus/copycats/mixin/compat/rubidium/BlockOcclusionCacheMixin.java
+++ b/common/src/main/java/com/copycatsplus/copycats/mixin/compat/rubidium/BlockOcclusionCacheMixin.java
@@ -1,5 +1,7 @@
 package com.copycatsplus.copycats.mixin.compat.rubidium;
 
+import com.copycatsplus.copycats.compat.Mods;
+import com.copycatsplus.copycats.foundation.annotation.ModMixin;
 import com.copycatsplus.copycats.foundation.copycat.ICopycatBlock;
 import net.minecraft.core.BlockPos;
 import net.minecraft.core.Direction;
@@ -14,6 +16,7 @@
 /**
  * Makes sure that copycat blocks are not occluded by Rubidium
  */
+@ModMixin(requiredMods = Mods.SODIUM)
 @Mixin(targets = "me.jellysquid.mods.sodium.client.render.chunk.compile.pipeline.BlockOcclusionCache")
 @Pseudo
 public class BlockOcclusionCacheMixin {
diff --git a/common/src/main/java/com/copycatsplus/copycats/mixin/compat/rubidium/BlockRendererMixin.java b/common/src/main/java/com/copycatsplus/copycats/mixin/compat/rubidium/BlockRendererMixin.java
index 856b096fd..7d5d57061 100644
--- a/common/src/main/java/com/copycatsplus/copycats/mixin/compat/rubidium/BlockRendererMixin.java
+++ b/common/src/main/java/com/copycatsplus/copycats/mixin/compat/rubidium/BlockRendererMixin.java
@@ -1,5 +1,7 @@
 package com.copycatsplus.copycats.mixin.compat.rubidium;
 
+import com.copycatsplus.copycats.compat.Mods;
+import com.copycatsplus.copycats.foundation.annotation.ModMixin;
 import com.copycatsplus.copycats.foundation.copycat.multistate.MultiStateRenderManager;
 import com.copycatsplus.copycats.foundation.copycat.multistate.MultiStateTextureAtlasSprite;
 import me.jellysquid.mods.sodium.client.model.color.ColorProvider;
@@ -18,6 +20,7 @@
  * <p>
  * Rubidium compatible version of {@link com.copycatsplus.copycats.mixin.foundation.copycat.multistate.ModelBlockRendererMixin}.
  */
+@ModMixin(requiredMods = Mods.SODIUM)
 @Mixin(BlockRenderer.class)
 @Pseudo
 public class BlockRendererMixin {