diff --git a/.github/workflows/upstream.yml b/.github/workflows/upstream.yml
new file mode 100644
index 000000000..52bb94655
--- /dev/null
+++ b/.github/workflows/upstream.yml
@@ -0,0 +1,24 @@
+name: Qiskit Upstream Tests
+on:
+  schedule:
+    # Run every Monday at 00:00 UTC
+    - cron: "0 0 * * 1"
+  pull_request:
+    paths:
+      - ".github/workflows/upstream.yml"
+  workflow_dispatch: # Allow manual triggering
+
+concurrency:
+  group: ${{ github.workflow }}-${{ github.head_ref || github.run_id }}
+  cancel-in-progress: true
+
+jobs:
+  qiskit-upstream-tests:
+    name: 🐍⚛️
+    strategy:
+      fail-fast: false
+      matrix:
+        os: [ubuntu-24.04, macos-15, windows-2025]
+    uses: cda-tum/mqt-workflows/.github/workflows/reusable-qiskit-upstream.yml@v1.7
+    with:
+      runs-on: ${{ matrix.os }}
diff --git a/noxfile.py b/noxfile.py
index 96a680052..1410c7951 100644
--- a/noxfile.py
+++ b/noxfile.py
@@ -45,7 +45,8 @@ def _run_tests(
     session: nox.Session,
     *,
     install_args: Sequence[str] = (),
-    run_args: Sequence[str] = (),
+    extra_commands: Sequence[str] = (),
+    pytest_run_args: Sequence[str] = (),
 ) -> None:
     env = {"UV_PROJECT_ENVIRONMENT": session.virtualenv.location}
     if os.environ.get("CI", None) and sys.platform == "win32":
@@ -69,6 +70,10 @@ def _run_tests(
         *install_args,
         env=env,
     )
+    session.run(
+        *extra_commands,
+        env=env,
+    )
     session.run(
         "uv",
         "run",
@@ -78,7 +83,7 @@ def _run_tests(
         "--verbose",
         *install_args,
         "pytest",
-        *run_args,
+        *pytest_run_args,
         *session.posargs,
         "--cov-config=pyproject.toml",
         env=env,
@@ -97,13 +102,21 @@ def minimums(session: nox.Session) -> None:
     _run_tests(
         session,
         install_args=["--resolution=lowest-direct"],
-        run_args=["-Wdefault"],
+        pytest_run_args=["-Wdefault"],
     )
     env = {"UV_PROJECT_ENVIRONMENT": session.virtualenv.location}
     session.run("uv", "tree", "--frozen", env=env)
     session.run("uv", "lock", "--refresh", env=env)
 
 
+@nox.session(reuse_venv=True, venv_backend="uv", python=PYTHON_ALL_VERSIONS)
+def qiskit(session: nox.Session) -> None:
+    """Tests against the latest version of Qiskit."""
+    _run_tests(session, extra_commands=["uv", "pip", "install", "qiskit @ git+https://github.com/Qiskit/qiskit.git"])
+    env = {"UV_PROJECT_ENVIRONMENT": session.virtualenv.location}
+    session.run("uv", "pip", "show", "qiskit", env=env)
+
+
 @nox.session(reuse_venv=True)
 def docs(session: nox.Session) -> None:
     """Build the docs. Use "--non-interactive" to avoid serving. Pass "-b linkcheck" to check links."""